when it doesn't work

what happens when you try everything and nothing works?...... should you give up? keep trying.. what? how do you know when enough is enough.. when you've given/done as much as you possibly can?... when you need to accept the fact that that somethings ...even though they seem like they are in your control.. aren't. can we really control anything? or just try to minimize the effects of the unpleasant side effects and try to hold on to the joys??

i know.. way more philosophical that i need to be......